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Bio film prevention

The difficulty of eradicating biofilms due to antimicrobial resistance has led to the search of new strategies. One of the approaches is new therapeutic options with existing antibiotics and antimicrobials to avoid biofilm formation and the emergence of resistant bacterial population (Sun et al., 2013). Another hypothesis that is gaining huge importance is the prevention of biofilm formation. In this case, the most common strategy is the surface modification of the medical devices, by modification of the material used or the development of coatings. Examples of methodologies are presented in Table 4.4.

Table 4.4 Strategies to overcome antimicrobial resistance of medical device biofilms

Medical device



Titanium implants

Surface treatment of titanium implants allowed the locally controlled delivery of gallium or silver ions without the development of resistance and maintaining high osteointegrative potential.

Cochis et al. (2016)

Central venous catheters

Central venous catheters coated with the antiseptic chlorohexidine and silver-sulfadiazine reduce the risk of colonization.

Ostendorf et al. (2005)

Minocycline-rifampin-impregnated central venous catheter decreases the risk of catheter-associated infection.

Chatzinikolaou et al. (2003) and Hanna et al. (2004)

Urinary catheters

N,N'-(1,2-phenylene)dimaleimide- plus-PS-coated silicone catheters showed 40.9% and 35.6% of inhibition of P. aeruginosa and S. epidermidis adhesion, respectively.

Burton et al. (2006)


Tethered liquid perfluorocarbon

surface coating of tubing and catheters suppresses biofilm formation.

Leslie et al. (2014)

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