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Advances in pulmonary drug delivery


Inhaled Proteins and PeptidesMECHANISMS OF ABSORPTION AND CLEARANCEImmunogenicityNonclinical Development ConsiderationsEXAMPLES OF DEVELOPMENT CANDIDATES Inhaled rhDNase (Pulmozyme)Inhaled InsulinInhaled Human Growth HormonePTH1-34CyclosporineAlpha-1 AntitrypsinInhaled VaccinesAnti-lgEInhaled Gene TherapyFormulation ApproachesFUTURE DIRECTIONSSUMMARYREFERENCESInhaled Insulin. More Compelling than EverUNMET NEEDCurrent GuidelinesINSULIN TREATMENT NOW RECOMMENDED EARLIER IN THE TREATMENT REGIMEThe First GenerationClinical Efficacy of Inhaled InsulinReliability of DosingClinical Safety of Inhaled InsulinPulmonary SafetySUMMARYREFERENCESInhaled Therapeutic siRNA for the Treatment of Respiratory DiseasesDELIVERY OF THERAPEUTIC siRNA TO THE LUNGBARRIERS TO siRNA DELIVERY TO THE LUNGNONVIRAL FORMULATIONS FOR PULMONARY siRNA DELIVERYPolymer-Based siRNA Delivery SystemsPolyethylenimineChitosanPoly (D,L-Lactide-co-Glycolide)Other PolymersLipid-Based Delivery Systems for siRNAPeptidesRNAi-BASED THERAPY FOR THE TREATMENT OF LUNG CANCERFUTURE PERSPECTIVESUMMARYREFERENCESNew Molecules to Treat Asthma and COPDASTHMACOPDNEW MOLECULES TO TREAT ASTHMA AND COPDChemokine and Cytokine InhibitorsAntiproteasesAntioxidantsPDE InhibitorsPI3K Inhibitorsp38 Mitogen-Activated Protein Kinase InhibitorsNuclear Factor Kappa-B InhibitorsAntimicrobialsAntiageing MoleculesCONCLUSIONREFERENCESInhaled Anticancer AgentsDELIVERY OF INHALED ANTICANCER AGENTSAerosol DepositionTargeting Airway Deposition of DrugsFormulationsSolutionsDry PowdersLiposomesMicroparticlesNanoparticlesSwellable HydrogelsMicellesAerosol Delivery DevicesINHALED ANTICANCER AGENTSImmunologics/CytokinesChemotherapyPharmacokineticsPreclinical EfficacyInhaled Chemotherapeutic AgentsNucleoside AnalogsDoxorubicinLiposomal 9-NitrocamptothecinPlatinum AgentsGene TherapyAntisense TherapyBacteriaCLINICAL USE OF INHALED ANTICANCER AGENTSImmunologics/CytokinesChemotherapyGene TherapyADVERSE EFFECTSLIMITATIONS OF INHALED ANTICANCER AGENTSEnvironmental ContaminationUnanswered QuestionsSUMMARYREFERENCESInhaled Countermeasures for Respiratory Tract VirusesAEROSOL BIOLOGYSMALL ANIMAL MODELS AND AEROSOL TRANSMISSIONRESPIRATORY VIRUS INFECTIONCOUNTERMEASURES FOR RESPIRATORY TRACT INFECTIONSINFLUENZA VIRUS, A PROTOTYPICAL RESPIRATORY TRACT VIRUSCONTROLLING INFLUENZA VIRUS DISEASE BURDENMultiple formulations. BRIEF HISTORY OF INFLUENZA VACCINESLIVE-ATTENUATED INFLUENZA VACCINESPULMONARY DELIVERYPULMONARY DRUG DELIVERYAEROSOL INHALERSSAFETY OF AEROSOL VACCINESBENEFITS AND DRAWBACKS OF INHALED AGENTSCONSIDERATIONSSUMMARYREFERENCESPulmonary Delivery of Antibiotics for Respiratory InfectionsNEBULIZATIONDPIDPI DevicesPowder Production and Particle EngineeringADVERSE EFFECTS AND PATIENT COMPLIANCEADVANCED FORMULATIONS FOR PULMONARY DELIVERY OF ANTIMICROBIALSLiposomal FormulationNanoparticlesInhaled BacteriophageCONCLUSIONSREFERENCESInhaled LiposomesPULMONARY RATIONALE AND HISTORYCHALLENGES IN DEVELOPING PHARMACEUTICAL LIPOSOME FORMULATIONSAnalytical ChallengesManufacturing ChallengesCONSIDERATIONS FOR INHALED PRODUCTSBIOCOMPATIBILITY AND FATE OF LIPOSOMES IN THE LUNGTREATMENT OF LUNG INFECTIONS WITH INHALED LIPOSOMAL ANTIBIOTICSLiposomal CiprofloxacinLiposomal Amikacin (ARIKAYCE® Formerly ARIKACE)SUMMARYREFERENCESInhaled Traditional Chinese Medicine for Respiratory DiseasesINHALATION DELIVERY OF TCMNebulized SHLNebulized YuxingcaoNebulized QingkailingNebulized TanreqingNebulized AndrographolidesOther Nebulized TCMsINHALED TCM VIA MDI OR DPIRATIONALE FOR TCM INHALATION THERAPYSUMMARYREFERENCESBronchoprovocation Tests for the Evaluation of Drug Efficacy in AsthmaINDIRECT VERSUS DIRECT AIRWAY CHALLENGESDIRECT AIRWAY CHALLENGESMethacholine and Histamine ChallengesTarget PopulationContraindicationsSafety ConsiderationsOutcomes and Interpretation of ResultsINDIRECT AIRWAY CHALLENGESMannitol Inhalation ChallengeTarget PopulationSafety ConsiderationsOutcomes and Interpretation of ResultsAdenosine Monophosphate Inhalation ChallengeTarget PopulationSafety ConsiderationsOutcomes and Interpretation of ResultsTarget PopulationSafety ConsiderationsOutcomes and Interpretation of ResultsCONCLUSIONSUMMARYREFERENCES
 
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