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Advances in pulmonary drug delivery
Inhaled Proteins and Peptides
MECHANISMS OF ABSORPTION AND CLEARANCE
Immunogenicity
Nonclinical Development Considerations
EXAMPLES OF DEVELOPMENT CANDIDATES Inhaled rhDNase (Pulmozyme)
Inhaled Insulin
Inhaled Human Growth Hormone
PTH1-34
Cyclosporine
Alpha-1 Antitrypsin
Inhaled Vaccines
Anti-lgE
Inhaled Gene Therapy
Formulation Approaches
FUTURE DIRECTIONS
SUMMARY
REFERENCES
Inhaled Insulin. More Compelling than Ever
UNMET NEED
Current Guidelines
INSULIN TREATMENT NOW RECOMMENDED EARLIER IN THE TREATMENT REGIME
The First Generation
Clinical Efficacy of Inhaled Insulin
Reliability of Dosing
Clinical Safety of Inhaled Insulin
Pulmonary Safety
SUMMARY
REFERENCES
Inhaled Therapeutic siRNA for the Treatment of Respiratory Diseases
DELIVERY OF THERAPEUTIC siRNA TO THE LUNG
BARRIERS TO siRNA DELIVERY TO THE LUNG
NONVIRAL FORMULATIONS FOR PULMONARY siRNA DELIVERY
Polymer-Based siRNA Delivery Systems
Polyethylenimine
Chitosan
Poly (D,L-Lactide-co-Glycolide)
Other Polymers
Lipid-Based Delivery Systems for siRNA
Peptides
RNAi-BASED THERAPY FOR THE TREATMENT OF LUNG CANCER
FUTURE PERSPECTIVE
SUMMARY
REFERENCES
New Molecules to Treat Asthma and COPD
ASTHMA
COPD
NEW MOLECULES TO TREAT ASTHMA AND COPD
Chemokine and Cytokine Inhibitors
Antiproteases
Antioxidants
PDE Inhibitors
PI3K Inhibitors
p38 Mitogen-Activated Protein Kinase Inhibitors
Nuclear Factor Kappa-B Inhibitors
Antimicrobials
Antiageing Molecules
CONCLUSION
REFERENCES
Inhaled Anticancer Agents
DELIVERY OF INHALED ANTICANCER AGENTS
Aerosol Deposition
Targeting Airway Deposition of Drugs
Formulations
Solutions
Dry Powders
Liposomes
Microparticles
Nanoparticles
Swellable Hydrogels
Micelles
Aerosol Delivery Devices
INHALED ANTICANCER AGENTS
Immunologics/Cytokines
Chemotherapy
Pharmacokinetics
Preclinical Efficacy
Inhaled Chemotherapeutic Agents
Nucleoside Analogs
Doxorubicin
Liposomal 9-Nitrocamptothecin
Platinum Agents
Gene Therapy
Antisense Therapy
Bacteria
CLINICAL USE OF INHALED ANTICANCER AGENTS
Immunologics/Cytokines
Chemotherapy
Gene Therapy
ADVERSE EFFECTS
LIMITATIONS OF INHALED ANTICANCER AGENTS
Environmental Contamination
Unanswered Questions
SUMMARY
REFERENCES
Inhaled Countermeasures for Respiratory Tract Viruses
AEROSOL BIOLOGY
SMALL ANIMAL MODELS AND AEROSOL TRANSMISSION
RESPIRATORY VIRUS INFECTION
COUNTERMEASURES FOR RESPIRATORY TRACT INFECTIONS
INFLUENZA VIRUS, A PROTOTYPICAL RESPIRATORY TRACT VIRUS
CONTROLLING INFLUENZA VIRUS DISEASE BURDEN
Multiple formulations.
BRIEF HISTORY OF INFLUENZA VACCINES
LIVE-ATTENUATED INFLUENZA VACCINES
PULMONARY DELIVERY
PULMONARY DRUG DELIVERY
AEROSOL INHALERS
SAFETY OF AEROSOL VACCINES
BENEFITS AND DRAWBACKS OF INHALED AGENTS
CONSIDERATIONS
SUMMARY
REFERENCES
Pulmonary Delivery of Antibiotics for Respiratory Infections
NEBULIZATION
DPI
DPI Devices
Powder Production and Particle Engineering
ADVERSE EFFECTS AND PATIENT COMPLIANCE
ADVANCED FORMULATIONS FOR PULMONARY DELIVERY OF ANTIMICROBIALS
Liposomal Formulation
Nanoparticles
Inhaled Bacteriophage
CONCLUSIONS
REFERENCES
Inhaled Liposomes
PULMONARY RATIONALE AND HISTORY
CHALLENGES IN DEVELOPING PHARMACEUTICAL LIPOSOME FORMULATIONS
Analytical Challenges
Manufacturing Challenges
CONSIDERATIONS FOR INHALED PRODUCTS
BIOCOMPATIBILITY AND FATE OF LIPOSOMES IN THE LUNG
TREATMENT OF LUNG INFECTIONS WITH INHALED LIPOSOMAL ANTIBIOTICS
Liposomal Ciprofloxacin
Liposomal Amikacin (ARIKAYCE® Formerly ARIKACE)
SUMMARY
REFERENCES
Inhaled Traditional Chinese Medicine for Respiratory Diseases
INHALATION DELIVERY OF TCM
Nebulized SHL
Nebulized Yuxingcao
Nebulized Qingkailing
Nebulized Tanreqing
Nebulized Andrographolides
Other Nebulized TCMs
INHALED TCM VIA MDI OR DPI
RATIONALE FOR TCM INHALATION THERAPY
SUMMARY
REFERENCES
Bronchoprovocation Tests for the Evaluation of Drug Efficacy in Asthma
INDIRECT VERSUS DIRECT AIRWAY CHALLENGES
DIRECT AIRWAY CHALLENGES
Methacholine and Histamine Challenges
Target Population
Contraindications
Safety Considerations
Outcomes and Interpretation of Results
INDIRECT AIRWAY CHALLENGES
Mannitol Inhalation Challenge
Target Population
Safety Considerations
Outcomes and Interpretation of Results
Adenosine Monophosphate Inhalation Challenge
Target Population
Safety Considerations
Outcomes and Interpretation of Results
Target Population
Safety Considerations
Outcomes and Interpretation of Results
CONCLUSION
SUMMARY
REFERENCES
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