Desktop version

Home arrow Environment arrow Biosafety and the environmental uses of micro-organisms : conference proceedings.


In addition to direct biological effects of a GMM, including their potential for HGT, hazards may also be caused by indirect effects. Indirect effects may include consequences of the replacement of an existing technology by utilising one linked to the use of a GMM. The assessment of indirect effects can be complex and may require interdisciplinary approaches, including modelling to making predictions from small-scale experiences and contained uses to broader non-contained applications. This effort incorporated into a risk assessment of a GMM, as described above, is clearly rewarding if GMM technologies, as presented in this volume, are developed to improve the efficiency and environmental friendliness compared to current applications.


Allison, S.D. and J.B.H. Martiny (2008), “Resistance, resilience, and redundancy in microbial communities”, Proceedings of the National Academy of Sciences of the United States of America, No. 105, pp. 11 512-11 519.

Alphey, L., et al. (2002), “Malaria control with genetically manipulated insect vectors”, Science, No. 298, pp. 119 121.

Barriuso, J., J.R. Valverde and R.P. Mellado (2011), “Estimation of bacterial diversity using next generation sequencing of 16S rDNA: A comparison of different workflows”, BMC Bioinformatics, No. 12, pp. 473.

Berard, A., et al (2011), “Resilience of soil microbial communities impacted by severe drought and high temperature in the context of Mediterranean heat waves”, European Journal of Soil Biology, No. 47, pp. 333-342.

Brigulla, M. and W. Wackernagel (2010), “Molecular aspects of gene transfer and foreign DNA acquisition in prokaryotes with regard to safety issues”, Applied Microbiology and Biotechnology, No. 86, pp. 1 027-1 041.

Davison, J. (1999), “Genetic exchange between bacteria in the environment”, Plasmid, No. 42, pp. 73-91.

De La Cochetiere, M.F., et al. (2005), “Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge”, Journal of Clinical Microbiology, No. 43, pp. 5 588-5 592.

de Lorenzo, V. (2008), “Systems biology approaches to bioremediation”, Current Opinion in Biotechnology, No. 19, pp. 579-589.

de Lorenzo, V. (2009), “Recombinant bacteria for environmental release: What went wrong and what we have learnt from it”, Clinical Microbiology and Infection, No. 15, pp. 63-65.

Dethlefsen, L., et al (2008), “The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing”, PLoS Biology, No. 6, e280,

EFSA Panel on Genetically Modified Organisms (GMO) (2011a), “Guidance on the post-market environmental monitoring (PMEM) of genetically modified plants”, EFSA Journal, No. 9, pp. 2 316-2 355.

EFSA Panel on Genetically Modified Organisms (2011b), “Guidance on the risk assessment of genetically modified micro-organisms and their products intended for food and feed use”, EFSA Journal, No. 9, pp. 2 193-2 246.

Griffiths, B.S., et al. (2008), “Functional resilience of soil microbial communities depends on both soil structure and microbial community composition”, Biology and Fertility of Soils, No. 44, pp. 745-754.

Janssen, P.H., et al. (2002), “Improved culturability of soil bacteria and isolation in pure culture of novel members of the divisions Acidobacteria, Actinobacteria, Proteobacteria, and Verrucomicrobia”, Applied and Environmental Microbiology, No. 68, pp. 2 391-2 396.

Kuske, C.R., et al. (2012), “Response and resilience of soil biocrust bacterial communities to chronic physical disturbance in arid shrublands”, ISME Journal, No. 6, pp. 886-897.

Molin, S., et al. (1993), “Suicidal genetic elements and their use in biological containment of bacteria”, Annual Review of Microbiology, No. 47, pp. 139-166.

Moreira, L.A., et al. (2009), “A Wolbachia symbiont in Aedes Aegypti limits infection with dengue, chikungunya, and plasmodium”, Cell, No. 139, pp. 1 268-1 278.

OECD (Organisation for Economic Cooperation and Development) (2010), “Guidance Document on Horizontal Gene Transfer between Bacteria”, Series on Harmonisation of Regulatory Oversight in Biotechnology, No. 50, OECD, Paris,

OECD (2008), “Consensus Document on Information Used in the Assessment of Environmental Applications Involving Acinetobacter”, Series on Harmonisation of Regulatory Oversight in Biotechnology, No. 46, OECD, Paris,

OECD (2006), “Consensus Document on Information Used in the Assessment of Environmental Applications Involving Acidithiobacillus”, Series on Harmonisation of Regulatory Oversight in Biotechnology, No. 37, OECD, Paris,

OECD (1997), “Consensus Document on Information Used in the Assessment of Environmental Applications Involving Pseudomonas”, Series on Harmonisation of Regulatory Oversight in Biotechnology, No. 6, OECD, Paris,

OECD (1986), “Recombinant DNA considerations”, OECD, Paris,

Rvan, P.R., et al. (2009), “Rhizosphere engineering and management for sustainable agriculture”, Plant and Soil, No. 321, pp. 363-383.

Schwieger, F. and C.C. Tebbe (2000), “Effect of field inoculation with

Sinorhizobium meliloti L33 on the composition of bacterial communities in rhizospheres of a target plant (Medicago sativa) and a non target plant (Chenopodium album) - Linking of 16S rRNA gene-based single-strand conformation potymorphism communitv profiles to the diversitv of cultivated bacteria”, Applied and Environmental Microbiology, No. 66, pp. 3 556-3 565.

Schwieger, F., et al. (2000), “Field Rsimeter investigation with luciferase-gene (luc)- tagged Sinorhizobium meliloti strains to evaluate the ecological significance of soil inoculation and a recA mutation”, Soil Biology and Biochemistry, No. 32, pp. 859-868.

Selbitschka, W., et al. (2006), “Long-term field release of bioluminescent Sinorhizobium meliloti strains to assess the influence of a recA mutation on the strains’ survival”, Microbial Ecology, No. 52, pp. 583-595.

Shokralla, S., et al. (2012), “Next-generation sequencing technologies for environmental DNA research”, Molecular Ecology, No. 21, pp. 1 794-1 805.

Silva-Rocha, R. and V. de Lorenzo (2010), “Noise and robustness in prokaryotic regulatory networks”, in: Gottesman, S. and C.S. Harwood (eds), Annual Review of Microbiology, Vol. 64, pp. 257-275.

Snow, A.A., et al. (2005), “Genetically engineered organisms and the environment: Current status and recommendations”, Ecological Applications, No. 15, pp. 377-404.

Stevenson, B.S., et al. (2004), “New strategies for cultivation and detection of previously uncultured microbes”, Applied and Environmental Microbiology, No. 70, pp. 4 748-4 755.

Tebbe, C.C. and R. Miethling-Graff (2006), “Marker genes as tools to study deliberately released soil bacteria”, in: Nannipieri, P.S. and K. Smalla (eds), Nucleic Acids and Proteins in Soil, pp. 421-447, Springer, Heidelberg.

Thomas, C.M. and K.M. Nielsen (2005), “Mechanisms of, and barriers to, horizontal gene transfer between bacteria”, Nature Reviews of Microbiology, No. 3, pp. 711-721.

Torres, B., et al. (2000), “A gene containment strategy based on a restriction-modification

system”, Environmental Microbiology, No. 2, pp. 555-563.

Van Bruggen, A.H.C., et al. (2006), “Relation between soil health, wave-like fluctuations in microbial populations, and soil-borne plant disease management", European Journal of Plant Pathology, No. 115, pp. 105-122.

< Prev   CONTENTS   Source   Next >