Attention, Genes, and ADHD - Attention, Genes, and ADHD -

The Aims of Behaviour Genetics Why are People Different?The Tools of Behaviour Genetics An Example of Genetic Analysis of ADHD What is ADHD?The Australian Twin ADHD Project (ATAP)How common are symptoms of ADHD in these families?Are there key correlated behaviours?Testing for zygosity What are the genetics of ADHD symptom number?What is it like being a twin?Is ADHD a Continuum or a Discrete Category?Multivariate genetic analysis and the relationship between measures Extensions of the twin design Discussion References : The Diagnostic Genetics of ADHD Symptoms and Subtypes Diagnostic Genetics Categorical Versus Dimensional Systems Heritability Australian Twin ADHD Project (ATAP)Concordance Data Genetic Analysis Item Analysis Univariate Item Analysis Multivariate Item Analysis Discussion References : The Developmental Genetics of ADHD Stability and Changes in Symptomatology The Long-Term Outcome of ADHD Psychopathology in Adult Relatives of Young People with ADHD Trends in Molecular Studies Discussion : Familial and Genetic Bases of Speech and Language Disorders The Search for Phenotype Definitions Studies of Phenotypes Incidence/Prevalence Gender as a Risk Factor Familial Aggregation Studies that Suggest a Genetic Component/Genetic Studies Comorbid Disorders Studies of children with comorbid speech and language disorders Pilot Data Genetic Explanations Summary References : Comorbidity of Reading/Spelling Disability and ADHD Defining Reading and Spelling Disabilities Epidemiological Evidence for the High Comorbidity of ADHD and RSD Quantitative Genetic Studies of RSD Molecular Genetic Studies of RSD Evidence for Shared Genetic Influences on ADHD and RSD Conclusions References : Causes of the Overlap Among Symptoms of ADHD, Oppositional Defiant Disorder, and Conduct Disorder Method Assessment of ADHD, ODD, and CD symptoms.Results Discussion References : Aetiology of the Sex Difference in the Prevalence of DSM-III-R ADHD: A Comparison of Two Models Differences Between ADHD Boys and Girls SEX DIFFERENCES IN THE PREVALENCE OF ADHD Present Study Results Discussion References : Single Gene Studies of ADHD Introduction Genetics Molecular Studies Recent Studies Investigating Single Genes Gene to Brain Fragile-X Syndrome References : Molecular Genetics of ADHD Introduction Characterisation of the ADHD Phenotype for Genetic Studies Design of Studies for Molecular Genetics Molecular Genetics Genetic Data Analyses Molecular Genetic Studies of ADHD Summary and Future Directions References : The Genetic Relationship Between ADHD and Gilles De La Tourette Syndrome Phenomenology and Natural History of ADHD Neuropsychological Assessment of GTS and ADHD Neuropsychology of GTS Neuropsychology of comorbid GTS and ADHD Familial relationship between GTS and ADHD Molecular Genetic Studies of GTS and ADHD Summary References : Implications of Genetic Studies of Attention Problems for Education and Intervention Diagnosis Comorbidity Intervention Family Dynamics Language and ADHD Comorbidity and Schooling Implications of Molecular Genetics Ethical Issues Agenda for Psychiatric Genetics Conclusion Clearer identification of ADHD subtypes References : Child Psychiatry in the Era Following Sequencing the Genome Introduction CLINICAL CONCEPTS ADHD as a diagnostic category ADHD as a multifactorial disorder ADHD as a coinorbid disorder ADHD as a predominantly male disorder GENETIC RISK MECHANISMS Mode of operation of genetic risk factors Universality of genetic risks Strength of genetic effects “Good” genes and “bad” genes Searching for Susceptibility Genes Association methods Quantitative trait loci (QTL) approaches FINDING OUT WHAT GENES DO How will sequencing the genome help?How do genes function?Clinical Benefits of Genetic Research Pharmacogenetics Nature-nurture interplay Diagnosis Genetic screening Counselling Ethical issues Conclusion References