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Degenerative Disorders of the Brain

: Brain circuitry in ageing and neurodegenerative disease Introduction Cortico-basal ganglia and cortico-cerebellar circuits: structure and function The ageing brain: changes in structure, function, and metabolic integrity Structural changes in the aged brain Functional changes in the aged brain Differences in chronological versus brain age Cortico-basal ganglia and fronto-cerebellar networks in ageing and neurodegeneration Concluding remarks Abbreviations Further reading References : Alzheimer’s disease: prodromal stages and dementia Introduction Diagnostic considerations Neuropathology and biomarkers Prevalence and risk factors Clinical vignette Neuropsychology Treatment and management Concluding remarks Abbreviations Further reading References : Parkinson’s disease Introduction Preliminary considerations Clinical vignette Diagnostic considerations Biomarkers Epidemiology Genetics Neuropsychology Neuromodulation Treatment Concluding remarks Abbreviations Further reading References : Huntington’s disease Introduction Prevalence Clinical vignette Diagnostic considerations Genetics and gene testing Juvenile-onset Huntington’s disease Neuropathology, neurophysiology and potential biomarkers Clinical symptoms Everyday functioning, care and health-related quality of life Concluding remarks Abbreviations Further reading References : Experience-dependent modulation of neurodegenerative disorders: Huntington’s disease as an exemplar Introduction Preclinical models of Huntington’s disease Experience-dependent modulators of Huntington’s disease Enviromimetics as a therapeutic lead for Huntington’s disease Concluding remarks Abbreviations Notes Further reading References : Fragile X-associated tremor ataxia syndrome Introduction Preliminary considerations Clinical vignette Onset and prevalence Clinical signs and symptoms Diagnostic instruments and clinical rating scales Neuropsychology Neuropathology/neurobiological mechanisms Treatment including psychopharmacology Concluding remarks Abbreviations Further reading References : Multiple sclerosis Introduction Preliminary considerations Epidemiology Etiology Neuropathology Clinical presentation Diagnosis Clinical course Clinical vignette Measures of disease status and progression Treatment Concluding remarks Abbreviations Further reading References : Dementia with Lewy bodies Introduction A brief epidemiology of dementia with Lewy bodies Neuropathology Clinical syndrome Wakefulness in dementia with Lewy bodies Concluding remarks Abbreviations Further reading References : Motor neuron disease Introduction Clinical vignette Epidemiology Clinical presentation Prognosis Genetic factors Diagnosis Novel diagnostic techniques Cognitive and behavioural manifestations The ALS–FTD continuum Management and potential therapeutic strategies Abbreviations Further reading References : New clinical neuroscience technologies for treating neurodegenerative disorders Introduction Transcranial magnetic stimulation in clinical neuroscience Transcranial electrical stimulation: old application, new uses Concluding remarks Abbreviations and glossary References

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