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Advantages, Disadvantages and Limitations

Some advantages and limitations of the DIDGI® are provided in Table 8.2.

Fig. 8.4 Casein (a) and β-lactoglobulin (b) concentrations determined by ELISA

Conclusion and Prospects

We present here the development of a simple and new dynamic digestion system, DIDGI® that has been validated against in vivo (porcine) data for the digestion of infant formula. The system is currently being applied to study (1) the digestion of

Table 8.2 Advantages and limitations of DIDGI®

Advantages

Limitations

Capacity: Full meals up to 200 mL

No simulation of nutrient absorption

Temporal simulation: Real-time digestion and monitoring of pH and temperature

No simulation of the biomechanical aspects of food digestion (stomach contractions, peristalsis…)

Possibility of modifying the atmosphere and work in controlled gas conditions

Bioreactors do not mimic the anatomy of the gut compartments

Meals: any masticated food/drink matrix

Satiety: no in vivo satiety signals controlling rate of digestion

Transparent: visual observations possible during gastric processing

Orientation: Vertical alignment of main body and antrum

Model validated against in vivo data

human milk, dairy gels and emulsions, cheese, and (2) the survival of food microorganisms in the gastro-intestinal tract. The results obtained so far are quite promising. Some improvements have recently been applied to the system: it now has three compartments (stomach, duodenum and jejunum + ileum) instead of two; dialysis membranes will soon be added to the system to mimic absorption; the pump allowing the bolus to enter the stomach has been modified to allow the introduction of solid matrices (meat, bread, fruits and vegetables).

References

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