Blending Technological Innovations into Long-Term Prospective Research
CARLOS N. PATO, JANET L. SOBELL, AND MICHELE T. PATO
Increasing technological advancement coupled with decreasing costs are allowing whole-genome sequencing of a large number of humans to become a powerful strategy for the identification of disease risk variants. The richness of genotypic data must be paralleled by an equally comprehensive phenotypic characterization. This chapter describes one such investigation, namely, the Genomic Psychiatry Cohort (GPC), which was designed with both cross-sectional and longitudinal arms. This design has enabled the rapid acquisition of biological samples (i.e., DNA, RNA, plasma) for genetic analysis on tens of thousands of subjects. Our continued contact with GPC participants will allow an enrichment of phenotypes for studies of clinical course, treatment outcome, endophenotypes (e.g., structural and functional brain imaging), gene-environment interactions, and other analyses. The GPC is being expanded from its current focus on schizophrenia and bipolar disorder to also include individuals with obsessive compulsive disorder. This chapter reviews the background and development of the GPC and some highlights of genetic findings in schizophrenia and bipolar disorder.