Home Health Big Book of Emergency Department Psychiatry
Aripiprazole is listed as an atypical antipsychotic drug. Aripiprazole is available in oral and IM extended release forms; 10—15 mg/day is the recommended initial and target dose for the oral formulation (Apripiprazole 2016; Byrne 2007). The daily maximum dose is 30 mg. The IM extended- release formulation has an initial recommended dose of 400 mg with a maintenance dose of 400 mg/month (Apripiprazole 2016).
Quetiapine is listed as an atypical antipsychotic. It is available in an oral form. The recommended daily dose is 150—750 mg (Byrne 2007; Quetiapine 2016) after titrating up from an initial dose of 50 mg administered in 25 mg tablets twice a day. The maximum recommended daily dose is 750 mg.
Clozapine is listed as an atypical antipsychotic. Clozapine is available in oral tablets, dissolvable tablets, and in liquid oral forms. The initial recommended starting oral dose is 12.5 mg once or twice a day with a target dosage of 300—450 mg/day. The recommended maximum daily dose is 900 mg. The liquid oral formulation is available in 1 and 9 ml oral syringes (Clozapine 2016). Clozapine is well known for its calming effect on aggression, but is underutilized in the treatment of psychosis due to the health risks attached to its use, including agranulocytosis or low white blood cell counts, but it is turned to as an alternative treatment option when a patient has failed multiple trials of other antipsychotic medications (Byrne 2007; Mohr et al. 2005).
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