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Stimuli-Responsive Nanomicelles

pH Sensitive

The pH of tumor environment is acidic (6.5—7.2) compared with normal tissues (7.4). These differences in pH have been exploited to cleave the pH-sensitive ligands to release drugs from the micelles carriers. In a nutshell, under physiological condition (pH 7.4) drug molecules are entrapped inside nanomicelles. Therapeutic agents can be released selectively under acidic conditions such as tumor cell, endosomes, or lysosomes. Several pH-sensitive nanomicelles have been developed. The construct generated low toxicity and higher selectivity [68—72]. Anionic groups (poly acrylic acid, poly methacrylic acid, poly glutamic acid) and cationic groups (dimethylamino ethyl methacrylate, poly histidine) are common pH-sensitive components. For example, Bae et al. have prepared pH-sensitive poly(ethylene glycol)-poly(aspartate hydrazone adriamycin)—loaded nanomicelles, which release selectively in the low pH environment due to acid-sensitive hydrazine linker [73].

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