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The flagellar pocket

In all trypanosomatids, the flagellum emerges from a deep sac-like invagination of the plasma membrane close to the region where the basal body-kinetoplast complex is localized. At the deeper portion of the invagination, the membrane continues as the flagellar membrane. At the emergence site, the flagellar membrane comes into contact with the membrane that lines the cell body. Recent studies have shown that some cytoskeletal components concentrate in this region, forming what has been described as the flagellar pocket collar (FPC) that surrounds the whole flagellum and establishes contact with the subpellicular microtubules. A structure known as the bilobe, which is considered to be a Golgi complex-associated structure and contains centrin 2 and several other proteins, is also associated with the FPC. One

protein complex that is designated as BILBO1 is involved in the formation of the FPC in T. brucei. The knockout of this complex using RNAi disrupts the formation of the FPC. This molecular complex can form polymers in vitro.44 The complex organization of this system that establishes the membrane invagination forms a nearly complete and dynamic compartment that is the flagellar pocket.45

 
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