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Home arrow Economics arrow American Trypanosomiasis Chagas Disease, Second Edition: One Hundred Years of Research



Maternal—fetal transmission of T. cruzi can have severe outcomes by compromising survival and/or growth of fetus/neonate, and/or lead to severe clinical forms of chronic infection later in adult life, if infant remains untreated. Congenital T. cruzi infection can be found worldwide since such transmission can occur in endemic, as well as nonendemic areas receiving immigrants from endemic regions. Though often asymptomatic at birth and neglected, this congenital infection must be considered as an important public health problem requiring the development of reasonable prevention or control strategies, based on a deep understanding of mechanisms and multiple involved factors. Targeting the group of infected pregnant women at risk of transmission and a reliable diagnosis of neonates displaying a “successful” congenital infection (particularly molecular tests identifying live parasites) are two particularly important points to be improved for a better efficacy of health systems in charge of controlling congenital Chagas disease.

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