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Home arrow Economics arrow American Trypanosomiasis Chagas Disease, Second Edition: One Hundred Years of Research



The author wishes to acknowledge Dr. Barbara Burleigh for useful discussions about the contents of this chapter and critical reading of the manuscript.


AMP adenosine monophosphate

ASM lysosomal acid sphingomyelinase

BMDM mouse bone marrow-derived macrophages

B2R B2 bradykinin receptor

Ca21 calcium ion

CHO cells Chinese hamster ovary cells

CLASP1 microtubule cytoplasmic linker associated protein-1

E-64 an irreversible inhibitor of cysteine proteases. Chemical name (1S,2S)-2-

(((S)-1-((4-guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl) cyclopropanecarboxylic acid FACS fluorescence-activated cell sorting

G protein guanine nucleotide-binding protein

GFP green fluorescent protein

Gp82 Trypanosoma cruzi metacyclic trypomastigote-specific surface glycoprotein

Gp85 Trypanosoma cruzi Gp85 glycoproteins, members of the Gp85/Trans-siali-

dase superfamily

HOE a potent antagonist of the bradkynin-2 receptor. Chemical name Arg-(3-hyp-

5-thi-7-tic-9-oic)-9-desarg-bradykinin IFN interferon

IFNAR interferon-a/в receptor


IFN-в interferon в

IFN-y interferon y

IRF3 interferon regulatory transcription factor 3

IRF9 interferon regulatory factor 9

ISGs interferon-stimulated genes

JAK1 Janus Kinase 1

LAMP-1 lysosomal-associated membrane protein

LC3 microtubule-associated protein 1A/1B-light chain 3

LRV1 Leishmania RNA virus

MDA5 melanoma differentiation associated gene 5

mTOR mammalian target of rapamycin

MyD88 myeloid differentiation factor 88

NK cell natural killer cell

NKT cell natural killer T cell

NOD nucleotide-binding oligomerization domain receptor


PI3K phosphoinositide 3-kinase

RIG-I retinoic-acid-inducible protein I

RLGs RIG-I like receptors

RNAi RNA interference

SAP T. cruzi serine-, alanine-, and proline-rich proteins

STAT1 signal transducer and activator of transcription 1

STAT2 signal transducer and activator of transcription 2

TBK1 TANK-binding kinase 1

TcSMP T. cruzi surface membrane proteins

TIR toll/interleukin-1 receptor

TLR3 Toll-like receptor 3

TLR4 Toll-like receptor 4

TLRs Toll-like receptors

TRIF domain-containing adaptor protein inducing interferon beta

TSSA VI trypomastigote small surface antigen present in T. cruzi lineage VI TYK2 tyrosine kinase 2

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