Home Health DNA Modifications in the Brain. Neuroepigenetic Regulation of Gene Expression
DNA methylation, for a long time regarded as a stable DNA modification that controls cellular differentiation, is now widely accepted to be dynamically regulated in the nervous system and plays an essential role in memory formation and adaptation to an ever-changing environment. Dynamic changes in DNA methylation occur in postmitotic neurons; the methylation-mediated chromatin remodeling may play critical roles in gene expression modulation involved in long-lasting neuronal responses. DNA methylation represents one of the most permanent mechanisms of cellular memory. In support of this view, most differentiated cells have a rather small activity of DNMTs. Although the mature brain consists mainly of terminally differentiated postmitotic cells, surprisingly, high levels of DNA methylation and demethylation activities persist throughout the whole life.
This work was supported by Russian Science Foundation grant no. 14-50-00029.
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