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Home arrow Computer Science arrow Computational Diffusion MRI: MICCAI Workshop, Athens, Greece, October 2016

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Herein we used Diffusion Tensor Imaging study to reveal changes in brain connectivity associated with SWEDD or Parkinson group compared to control group.

One way ANOVA analysis revealed significant difference between QA and GFA of left cingulum and QA of the right cingulum between groups. Tukey post-hoc test

Table 2 Result of quantitative measurements of diffusion MRI in control, PD and SWEDD

PD

SWEDD

Normal

GFA of the left cingulum (mean±SD)

0.55±0.085

0.47±0.091

0.45±0.051

QA of left cingulum (mean±SD)

0.102±0.005

0.096 ±0.006

0.101 ±0.008

GFA of the right cingulum (mean±SD)

0.49±0.078

0.52±0.102

0.51±0.064

QA of the right cingulum (mean±SD)

0.098±0.006

0.102 ±0.004

0.107 ±0.007

Table 3 ANOVA and post hoc multiple comparisons of diffusion parameters of left and right cingulum

Diffusion parameter of a fibers

ANOVA

P-value

Post hoc multiple comparisons

P-value after

Bonferroni

correction

GFA of the left cingulum

0.000

Controls vs. PD

< 0.001

SWEDD vs. PD

0.002

QA of the left cingulum

0.007

SWEDD vs. PD

0.011

QA of the right cingulum

0.038

SWEDD vs. PD

0.031

Controls vs. PD

< 0.001

SWEDD vs. Control

0.049

was used to analyses between groups difference. The mean ± SD for each diffusion parameter in each group is depicted in Table 2. Homogeneity of variances was met for all tested variables using Leven’s test of homogeneity of variances, except for QA of right cingulum which was further analyzed by the Welch ANOVA and post- hoc Games-Howel test. For the ANOVA, a non-corrected p-value of < 0.05 was considered significant. Conditional on a significant F-value, post hoc pairwise t- tests were used and controlled with Bonferroni correction for multiple comparisons. Table 3 shows significant results of analysis of QA and GFA of cingulum between groups.

 
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