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Home arrow Computer Science arrow Computational Diffusion MRI: MICCAI Workshop, Athens, Greece, October 2016

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Method

Participants

Participants in this study were recruited from MCIC collection. The Mental Illness and Neuroscience Discovery (MIND) Institute, now the Mind Research Network formed the MIND Clinical Imaging Consortium (MCIC) in 2003 to conduct a multi-institutional, cross-sectional study of patients with schizophrenia and demo- graphically matched, by sex and age, healthy control. Diffusion weighted images (DWI) were obtained for 29 patients and 32 healthy controls. Sample demographics are shown in Table 1. A Structured Clinical Interview for DSM-IV (SCID/SCID-NP for controls) (First) or the Comprehensive Assessment of Symptoms and History (CASH) were used to diagnose primary and co-morbid psychiatric disorders in controls and patients. Patients were interviewed with the Scale for Assessment of Negative Symptoms (SANS), Scale for Assessment of Positive Symptoms (SAPS), and the Calgary Depression Scale for Schizophrenia (CDSS) to record symptoms and their current severity. The healthy control subjects with no current or past history of psychiatric illness including substance abuse or dependence were matched to the patient group for age and sex. All subjects provided informed consent to participate in the study that was approved by the human research committees.

Table 1 Subject demography

Patients with schizophrenia

Control subjects

Age

31.72±11.96

26.93±11.53

Sex (male/female)

22/7

26/6

Handedness (right/left)

28/1

30/2

Race (White) (N/%)

27/93.10%

29/90.62%

Subject education

12.9±62.22

14.04±1.55

Subject socioeconomic status

2.78±0.42

3.85±0.90

Total positive symptoms

5.10±2.28

-

Total negative symptoms

8.51±3.38

-

 
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