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Dyslipidemia

Blood lipids are strongly associated with body size and adiposity. Hypertriglyceridemia may result from the overproduction of very low-density lipoprotein (VLDL) and many patients with elevated triglycerides also have insulin resistance that causes the overproduction of VLDL [3]. Hypercholesterolemia is also common in obesity, which manifests as elevated low-density lipoprotein (LDL). Calorie excess raises hepatic synthesis of lipoproteins and results in glucose intolerance [4].

Bariatric surgery resulted in significant weight loss that has a marked effect on serum lipid levels as reported by Feingold et al. [5]. The low-carbohydrate diet pre- and postsurgery decreases triglyceride levels to a greater extent than high-carbohydrate diets, and produces marked weight loss differences. The human lipoprotein kinetic study of 2014 showed the effects of bariatric surgery on triglyceride-rich lipoproteins in decreasing cardiovascular mortality after surgery [6].

Batsis et al. reported on bariatric surgery improvement of cardiovascular risk factors in a geriatric population with significant reductions in weight, diabetes, hypertension, dyslipidemia, and sleep apnea [7]. Weight loss at 6 months postbariatric surgery produced an effective reduction in cardiovascular disease, diabetes, and related mortality as observed in a short-term study by Domienik-Karlowicz et al. [8] and management survey of endocrine diseases by Corcellas et al. [9].

Laparoscopic sleeve gastrectomy (LSG) weight loss improved levels of C-reactive proteins—markers of inflammation—dyslipidemia, and cancer antigen-125 (CA-125), linked to obesity and tumors [10].

 
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